Optimization of personalized therapies for anticancer treatment
نویسندگان
چکیده
منابع مشابه
The Molecular Aspects of Personalized Anticancer Treatment
Only 25% of cancer patients, on average, benefit from therapy. Even in the cases of complete clinical response the tumor progression is an event of high level expectation. The main reasons for tumor progression are: intratumor heterogeneity resulted from clonal evolution, drug resistance, and tumor-promoting microenvironment. The reprogramming of microenvironmental stromal-inflammatory componen...
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چکیده ندارد.
15 صفحه اولPPARs and Anticancer Therapies
1Department of Radiation Oncology, Brain Tumor Center of Excellence, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA 2 Institute for Radioprotection and Nuclear Safety, 92262 Fontenay aux Roses Cedex, France 3Vascular Biology Program, Children’s Hospital, Harvard Medical Center, Boston, MA 02115, USA 4Department of Pediatric Oncology, Dana-Fa...
متن کاملCircadian pharmacodynamics of anticancer therapies.
Circadian variation in drug metabolism and tissue sensitivity to drugs affects their activity and toxicity. A growing body of data suggests that therapy may be improved and toxicity reduced by administering antineoplastic agents at carefully selected times of the day. Here I briefly review molecular, cellular, and organismic time-keeping mechanisms as well as cytokinetic, pharmacokinetic, and p...
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Historically, approaches to improve cancer therapy have focused primarily on achieving increased tumor cell kill. Recently however another treatment approach has garnered considerable attention. Rather than targeting the neoplastic cell population directly, this strategy endeavors to impair the tumor’s nutritional support system by target the tumor blood vessel network. Vascular targeting appro...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2013
ISSN: 1752-0509
DOI: 10.1186/1752-0509-7-31